Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Mar 11:32:113.
doi: 10.11604/pamj.2019.32.113.12669. eCollection 2019.

Desmoplastic infantile ganglioglioma

Salma Kamoun  1 , Heifa Azouz  1 , Marwa Zemmali  2 , Slim Haouet  1 , Nidhameddine Kchir  1
Affiliations
Case Reports

Desmoplastic infantile ganglioglioma

Salma Kamoun et al. Pan Afr Med J. .

Abstract

The term desmoplastic infantile ganglioglioma was coined by VandenBerg et al in 1987. In their first report these authors referred to a rare, distinct brain tumor. About 60 cases of desmoplastic infantile ganglioglioma have been described in the literature since its first description. We report a case of a 6-year-old girl who was admitted for seizure without family history. Magnetic resonance imaging scan showed a hypodense area in the right temporal region. A right temporal craniotomy was performed and the tumor was excised. The pathologic examination revealed the diagnosis of desmoplastic infantile ganglioglioma.

Keywords: Tumor; central nervous system; infantile desmoplastic ganglioglioma.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Figure 1
Figure 1
Magnetic resonance imaging scan showing an area with contrast enhancing in the right temporal region
Figure 2
Figure 2
Spindled portion of the tumor, the cells have obviously eosinophilic cytoplasm and glial appearance
Figure 3
Figure 3
GFAP is strongly positive in the glial portion of the tumor, but negative in blood vessel and mesenchymal cells in the desmoplastic areas
Figure 4
Figure 4
Neuronal portion of tumor, cells range from atypical ganglionic cells to small polygonal cell types
Figure 5
Figure 5
Synaptophysin is positive in ganglion cells
See this image and copyright information in PMC

References

    1. VandenBerg SR, May EE, Rubinstein LJ, Herman MM, Perentes E, Vinores S, et al. Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential (“desmoplastic infantile gangliogliomas”) Report on 11 cases of a distinctive embryonal tumor with favorable prognosis. Journal of neurosurgery. 1987;66(1):58–71. - PubMed
    1. Iwami K-i. Desmoplastic infantile ganglioglioma. Child's Nervous System. 2007;23(6):619–20. - PubMed
    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. WHO Classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97–109. - PMC - PubMed
    1. Craver RD, Nadell J, Nelson JS. Desmoplastic infantile ganglioglioma. Pediatr Dev Pathol. 1999 Nov-Dec;2(6):582–7. - PubMed
    1. Prayson RA, Cohen ML, Kleinschmidt-De Masters B. Brain Tumors. 2009.

Publication types