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. 2019 Jun 20;9(6):146.
doi: 10.3390/brainsci9060146.

Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster

Christina M Sheerin  1 , Laurel V Kovalchick  2 , Cassie Overstreet  3 , Lance M Rappaport  4   5 , Vernell Williamson  6 , Vladimir Vladimirov  7 , Kenneth J Ruggiero  8 , Ananda B Amstadter  9
Affiliations

Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster

Christina M Sheerin et al. Brain Sci. .

Abstract

: Genes, environmental factors, and their interplay affect posttrauma symptoms. Although environmental predictors of the longitudinal course of posttraumatic stress disorder (PTSD) symptoms are documented, there remains a need to incorporate genetic risk into these models, especially in youth who are underrepresented in genetic studies. In an epidemiologic sample tornado-exposed adolescents (n = 707, 51% female, Mage = 14.54 years), trajectories of PTSD symptoms were examined at baseline and at 4-months and 12-months following baseline. This study aimed to determine if rare genetic variation in genes previously found in the sample to be related to PTSD diagnosis at baseline (MPHOSPH9, LGALS13, SLC2A2), environmental factors (disaster severity, social support), or their interplay were associated with symptom trajectories. A series of mixed effects models were conducted. Symptoms decreased over the three time points. Elevated tornado severity was associated with elevated baseline symptoms. Elevated recreational support was associated with lower baseline symptoms and attenuated improvement over time. Greater LGLAS13 variants attenuated symptom improvement over time. An interaction between MPHOSPH9 variants and tornado severity was associated with elevated baseline symptoms, but not change over time. Findings suggest the importance of rare genetic variation and environmental factors on the longitudinal course of PTSD symptoms following natural disaster trauma exposure.

Keywords: G × E; PTSD; adolescent risk; longitudinal; natural disaster trauma; rare variants.

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Conflict of interest statement

The authors disclose no conflicts of interest.

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References

    1. Liu H., Petukhova M.V., Sampson N.A., Aguilar-Gaxiola S., Alonso J., Andrade L.H., Bromet E.J., De Girolamo G., Haro J.M., Hinkov H., et al. Association of DSM-IV Posttraumatic Stress Disorder With Traumatic Experience Type and History in the World Health Organization World Mental Health Surveys. JAMA Psychiatry. 2017;74:270–281. doi: 10.1001/jamapsychiatry.2016.3783. - DOI - PMC - PubMed
    1. Galea S., Nandi A., Vlahov D. The Epidemiology of Post-Traumatic Stress Disorder after Disasters. Epidemiologic Rev. 2005;27:78–91. doi: 10.1093/epirev/mxi003. - DOI - PubMed
    1. Neria Y., Nandi A., Galea S. Post-traumatic stress disorder following disasters: A systematic review. Psychol. Med. 2008;38:467–480. doi: 10.1017/S0033291707001353. - DOI - PMC - PubMed
    1. Norris F.H., Friedman M.J., Watson P.J., Byrne C.M., Diaz E., Kaniasty K. 60,000 Disaster Victims Speak: Part I. An Empirical Review of the Empirical Literature, 1981–2001. Psychiatry. 2002;65:207–239. doi: 10.1521/psyc.65.3.207.20173. - DOI - PubMed
    1. Lee I., Ha Y.S., A Kim Y., Kwon Y.H. PTSD Symptoms in Elementary School Children After Typhoon Rusa. J. Korean Acad. Nurs. 2004;34:636. doi: 10.4040/jkan.2004.34.4.636. - DOI - PubMed

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