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Review
. 2019 Oct 1:221:94-112.
doi: 10.1016/j.carbpol.2019.05.067. Epub 2019 May 26.

Review of polysaccharide particle-based functional drug delivery

Thomas G Barclay  1 , Candace Minhthu Day  2 , Nikolai Petrovsky  3 , Sanjay Garg  4
Affiliations
Review

Review of polysaccharide particle-based functional drug delivery

Thomas G Barclay et al. Carbohydr Polym. .

Abstract

This review investigates the significant role polysaccharide particles play in functional drug delivery. The importance of these systems is due to the wide variety of polysaccharides and their natural source meaning that they can provide biocompatible and biodegradable systems with a range of both biological and chemical functionality valuable for drug delivery. This functionality includes protection and presentation of working therapeutics through avoidance of the reticuloendothelial system, stabilization of biomacromolecules and increasing the bioavailability of incorporated small molecule drugs. Transport of the therapeutic is also key to the utility of polysaccharide particles, moving drugs from the site of administration through mucosal binding and transport and using chemistry, size and receptor mediated drug targeting to specific tissues. This review also scrutinizes the methods of synthesizing and constructing functional polysaccharide particle drug delivery systems that maintain and extend the functionality of the natural polysaccharides.

Keywords: Carbohydrate; Functional drug-delivery; Hydrogel; Polysaccharide.

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Figures

Figure 1:
Figure 1:
Key benefits of polysaccharides in drug delivery systems
Figure 2:
Figure 2:
A graphic illustration of chitosan-based drug delivery system used to target asialoglycoprotein receptor
Figure 3:
Figure 3:
An example of CD-PEI complex synthesis
Figure 4:
Figure 4:
An illustration of chitosan-based drug enhancing nasal delivery through increased mucosal adhesion
Figure 5:
Figure 5:
Porous polysaccharide-based hydrogel
Figure 6:
Figure 6:
An illustration of a self-assembled polysaccharide hydrogel
Figure 7:
Figure 7:
Formation of polysaccharide hydrogel via ionic crosslinking
Figure 8:
Figure 8:
Nanohydrogel formation using the thiol-ene click reaction
See this image and copyright information in PMC

References

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