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Comment
. 2019 Jun 21;294(25):9720-9721.
doi: 10.1074/jbc.H119.009488.

Setting fire to fat

Affiliations
Comment

Setting fire to fat

Zhihui Zhang et al. J Biol Chem. .

Erratum in

  • Correction: Setting fire to fat.
    Zhang Z, Li MD. Zhang Z, et al. J Biol Chem. 2019 Jul 26;294(30):11653. doi: 10.1074/jbc.AAC119.009988. J Biol Chem. 2019. PMID: 31350285 Free PMC article. No abstract available.

Abstract

Adropin is a liver-secreted peptide that is crucial for metabolic health. However, the molecular functions and clinical significance of adropin have not been adequately explored. Butler et al. now investigate adropin expression profiles and links to cardiometabolic disease risk in two nonhuman primate models, increasing our translational and mechanistic understanding of this fascinating hormone.

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Conflict of interest statement

The authors declare that they have no conflicts of interest with the contents of this article

Figures

Figure 1.
Figure 1.
Circulating adropin level is negatively associated with biomarkers of cardiometabolic disease in a nonhuman primate model. Adropin precursor is expressed in the brain and liver plus other peripheral organs in nonhuman primates.

Comment on

References

    1. Butler A. A., Zhang J., Price C. A., Stevens J. R., Graham J. L., Stanhope K. L., King S., Krauss R. M., Bremer A. A., and Havel P. J. (2019) Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. J. Biol. Chem. 294, 9706–9719 10.1074/jbc.RA119.007528 - DOI - PMC - PubMed
    1. Kumar K. G., Trevaskis J. L., Lam D. D., Sutton G. M., Koza R. A., Chouljenko V. N., Kousoulas K. G., Rogers P. M., Kesterson R. A., Thearle M., Ferrante A. W. Jr., Mynatt R. L., Burris T. P., Dong J. Z., Halem H. A., et al. (2008) Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 8, 468–481 10.1016/j.cmet.2008.10.011 - DOI - PMC - PubMed
    1. Ghoshal S., Stevens J. R., Billon C., Girardet C., Sitaula S., Leon A. S., Rao D. C., Skinner J. S., Rankinen T., Bouchard C., Nuñez M. V., Stanhope K. L., Howatt D. A., Daugherty A., Zhang J., et al. (2018) Adropin: An endocrine link between the biological clock and cholesterol homeostasis. Mol. Metab. 8, 51–64 10.1016/j.molmet.2017.12.002 - DOI - PMC - PubMed
    1. Gao S., McMillan R. P., Zhu Q., Lopaschuk G. D., Hulver M. W., and Butler A. A. (2015) Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance. Mol. Metab. 4, 310–324 10.1016/j.molmet.2015.01.005 - DOI - PMC - PubMed
    1. Gao S., McMillan R. P., Jacas J., Zhu Q., Li X., Kumar G. K., Casals N., Hegardt F. G., Robbins P. D., Lopaschuk G. D., Hulver M. W., and Butler A. A. (2014) Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin. Diabetes 63, 3242–3252 10.2337/db14-0388 - DOI - PMC - PubMed

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