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. 2019:2018:269-285.
doi: 10.1007/978-1-4939-9581-3_13.

Rat Models of Metabolic Syndrome

Anne E Kwitek  1
Affiliations

Rat Models of Metabolic Syndrome

Anne E Kwitek. Methods Mol Biol. 2019.

Abstract

Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutant models, or are congenic strains derived from a combination of these models. Together they can be studied to identify the genetic and physiological underpinnings of MetS to identify candidate genes or mechanisms for study in human MetS subjects.

Keywords: Hypertension; MetS; Metabolic syndrome; Obesity; Rat disease model; Rat genetic model; Rat inbred model.

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Figures

Figure 1:
Figure 1:
Male LH/MavRrrcAek rats are glucose intolerant and hyperinsulimemic compared to LN/MavRrrcAek rats. Rats were fed a 10% fat diet (Research Diets D12450H) from wean. At 12 weeks of age Intraperitoneal Glucose Tolerance Tests (IPGTT) were performed on animals fasted 6 hours (+/− 0.5 hr) then given 2g glucose/kg body wt IP. Blood glucose and insulin levels were measured at 0, 30, 60, 90 and 120 minutes following glucose challenge. * P < 0.05, two-way ANOVA.
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