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Review
. 2019 Jul 1;115(9):1385-1392.
doi: 10.1093/cvr/cvz166.

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F J Ketelhuth  1   2 , Esther Lutgens  3   4   5 , Magnus Bäck  1 , Christoph J Binder  6 , Jan Van den Bossche  7 , Carolin Daniel  8 , Ingrid E Dumitriu  9 , Imo Hoefer  10 , Peter Libby  11 , Luke O'Neill  12 , Christian Weber  4   13 , Paul C Evans  14
Affiliations
Review

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F J Ketelhuth et al. Cardiovasc Res. .

Abstract

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

Keywords: Immune system; Inflammation; Metabolism; Vascular; Atherosclerosis.

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Figures

Graphical Abstract
Graphical Abstract
Figure 1
Figure 1
The role of immunometabolism in atherosclerosis. Pro-inflammatory and anti-inflammatory immune cells present distinct metabolic phenotypes. In general, M1 type macrophages, Th1, and Th17 cells are characterized by more catabolic metabolism, while M2 type macrophages and Tregs present bias towards more anabolic metabolism. Alterations in metabolism of immune cells carry the potential to influence plaque progression and stabilization. FA, fatty acid; FAO, fatty acid oxidation; IFNγ, interferon gamma; NLRP3, NACHT, LRR, and PYD domains-containing protein 3; OXPHOS, oxidative phosphorylation; PPP, pentose phosphate pathway; ROS, reactive oxygen species; TGFβ, growth factor beta; TNF, tumour necrosis factor.
See this image and copyright information in PMC

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