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Review
. 2019 Aug;35(3):285-293.
doi: 10.1016/j.cger.2019.03.001. Epub 2019 May 9.

Aging and Hematopoiesis

Emma M Groarke  1 , Neal S Young  2
Affiliations
Review

Aging and Hematopoiesis

Emma M Groarke et al. Clin Geriatr Med. 2019 Aug.

Abstract

In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in hematopoiesis may have clinical consequences: defective immune responses, cytopenias (most commonly anemia and lymphopenia), hematological malignancy, and effects mediated by hematopoietic cells in other organs. Clonal hematopoiesis is commonly seen with aging and has been associated with both blood concerns and atherosclerosis, but further study is required to determine a causative link.

Keywords: Anemia in the elderly; Clonal cytopenia of undetermined significance; Clonal hematopoiesis of indeterminate potential; Hematopoiesis.

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Conflict of interest statement

Disclosure Statement: The authors have nothing to disclose.

Figures

Fig. 1.
Fig. 1.
Distinction between ICUS, CHIP, CCUS, and MDS.
See this image and copyright information in PMC

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