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. 1988 Feb;9(2):331-2.
doi: 10.1093/carcin/9.2.331.

Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis

C E Elson  1 , T H Maltzman, J L Boston, M A Tanner, M N Gould
Affiliations

Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis

C E Elson et al. Carcinogenesis. 1988 Feb.

Abstract

d-Limonene was found to be effective in reducing the average number of rat mammary carcinomas that developed in 7,12-dimethylbenz[a]anthracene-treated rats when the terpene was fed during the initiation or during the promotion/progression stage of carcinogenesis. The time to the appearance of the first tumor was extended only when d-limonene was fed during the initiation stage. These effects could not be attributed to changes in mammary-relevant endocrine functions.

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