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. 2019 Aug 6;30(2):319-328.e8.
doi: 10.1016/j.cmet.2019.05.022. Epub 2019 Jun 20.

OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

Erwei Li  1 , Haili Shan  1 , Liqun Chen  1 , Aijun Long  1 , Yuanyuan Zhang  1 , Yang Liu  1 , Liangjie Jia  1 , Fangchao Wei  1 , Jinbo Han  1 , Tong Li  1 , Xiaohui Liu  2 , Haiteng Deng  3 , Yiguo Wang  4
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Free article

OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin

Erwei Li et al. Cell Metab. .
Free article

Abstract

Asprosin is a fasting-induced hormone that promotes glucose production in the liver and stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an unknown G protein-coupled receptor (GPCR). However, the bona fide receptor of Asprosin is unclear. Here, we have identified that the olfactory receptor OLFR734 acts as a receptor of Asprosin to modulate hepatic glucose production. Olfr734 knockout mice show a blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, and improved insulin sensitivity. As Olfr734 deficiency dramatically attenuates both fasting and high-fat-diet-induced glucose production, our results demonstrate a critical role of OLFR734 as a receptor of Asprosin to maintain glucose homeostasis during fasting and in obesity.

Keywords: OLFR734; asprosin; cAMP; gluconeogenesis.

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