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Review
. 2019 Jun 5:10:1227.
doi: 10.3389/fimmu.2019.01227. eCollection 2019.

Vaccination With Sporozoites: Models and Correlates of Protection

Yun Shan Goh  1 , Daniel McGuire  1   2 , Laurent Rénia  1   2   3
Affiliations
Review

Vaccination With Sporozoites: Models and Correlates of Protection

Yun Shan Goh et al. Front Immunol. .

Abstract

Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.

Keywords: Plasmodium falciparum; correlates; malaria; models; protection; sporozoites; vaccine.

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References

    1. WHO Malaria Fact Sheet. [online]. Available online at: http://www.who.int/mediacentre/factsheets/fs094/en/ (accessed January, 2019) (Online) (2018).
    1. Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, et al. . The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. (2015) 526:207–11. 10.1038/nature15535 - DOI - PMC - PubMed
    1. Hemingway J, Ranson H, Magill A, Kolaczinski J, Fornadel C, Gimnig J, et al. . Averting a malaria disaster: will insecticide resistance derail malaria control? Lancet. (2016) 387:1785–8. 10.1016/S0140-6736(15)00417-1 - DOI - PMC - PubMed
    1. Wiebe A, Longbottom J, Gleave K, Shearer FM, Sinka ME, Massey NC, et al. . Geographical distributions of African malaria vector sibling species and evidence for insecticide resistance. Malar J. (2017) 16:85. 10.1186/s12936-017-1734-y - DOI - PMC - PubMed
    1. Healer J, Cowman AF, Kaslow DC, Birkett AJ. Vaccines to accelerate malaria elimination and eventual eradication. Cold Spring Harb Perspect Med. (2017) 7:a025627. 10.1101/cshperspect.a025627 - DOI - PMC - PubMed

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