Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 May 21:9:155.
doi: 10.3389/fcimb.2019.00155. eCollection 2019.

Commentary: Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Baolei Jia  1 , Ruiming Wang  1 , Jie Zhang  1 , Yuxia Chi  1
Affiliations
Comment

Commentary: Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Baolei Jia et al. Front Cell Infect Microbiol. .
No abstract available

Keywords: bile acids; gut microbiome; immune regulation; liver cancer; soluble fiber.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Influence of refined soluble fibers on gut microbiota dysbiosis and liver health. The figure summarizes data from Singh et al. (2018).
See this image and copyright information in PMC

Comment on

  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.
    Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD Jr, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. Singh V, et al. Cell. 2018 Oct 18;175(3):679-694.e22. doi: 10.1016/j.cell.2018.09.004. Cell. 2018. PMID: 30340040 Free PMC article.

References

    1. Holscher H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut microbes 8, 172–184. 10.1080/19490976.2017.1290756 - DOI - PMC - PubMed
    1. Loo T. M., Kamachi F., Watanabe Y., Yoshimoto S., Kanda H., Arai Y., et al. . (2017). Gut Microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity. Cancer Discov. 7, 522–538. 10.1158/2159-8290.cd-16-0932 - DOI - PubMed
    1. Ma C., Han M., Heinrich B., Fu Q., Zhang Q., Sandhu M., et al. . (2018). Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science 360:eaan5931. 10.1126/science.aan5931 - DOI - PMC - PubMed
    1. Perry R. J., Peng L., Barry N. A., Cline G. W., Zhang D., Cardone R. L., et al. . (2016). Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome. Nature 534, 213–217. 10.1038/nature18309 - DOI - PMC - PubMed
    1. Pool-Zobel B. L. (2007). Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br. J. Nutr. 93, S73–S90. 10.1079/BJN20041349 - DOI - PubMed