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Editorial
. 2019 May 21:6:11.
doi: 10.21037/sci.2019.05.01. eCollection 2019.

A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells

Kesavan Meganathan  1 , Ramachandran Prakasam  1 , Kristen L Kroll  1
Affiliations
Editorial

A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells

Kesavan Meganathan et al. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Schematic depicts the interdependence between euchromatin maintenance by unstable regulators, transcriptional and translational status, and proliferation in stem cells, and demonstrates how levels of translation under optimal versus non-optimal growth conditions can act as a cellular rheostat to influence these cellular parameters. TF, transcription factor.
See this image and copyright information in PMC

Comment on

References

    1. Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, et al. The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell 2018;22:369-83.e8. 10.1016/j.stem.2018.02.004 - DOI - PMC - PubMed
    1. Gaspar-Maia A, Alajem A, Meshorer E, et al. Open chromatin in pluripotency and reprogramming. Nat Rev Mol Cell Biol 2011;12:36-47. 10.1038/nrm3036 - DOI - PMC - PubMed
    1. Efroni S, Duttagupta R, Cheng J, et al. Global transcription in pluripotent embryonic stem cells. Cell Stem Cell 2008;2:437-47. 10.1016/j.stem.2008.03.021 - DOI - PMC - PubMed
    1. Smith A. Formative pluripotency: the executive phase in a developmental continuum. Development 2017;144:365-73. 10.1242/dev.142679 - DOI - PMC - PubMed
    1. Ahmed K, Dehghani H, Rugg-Gunn P, et al. Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One 2010;5:e10531. 10.1371/journal.pone.0010531 - DOI - PMC - PubMed