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Editorial
. 2019 May 24:4:37.
doi: 10.21037/tgh.2019.05.09. eCollection 2019.

Proteomic heterogeneity reveals SOAT1 as a potential biomarker for hepatocellular carcinoma

Subreen A Khatib  1   2 , Xin Wei Wang  1   3
Affiliations
Editorial

Proteomic heterogeneity reveals SOAT1 as a potential biomarker for hepatocellular carcinoma

Subreen A Khatib et al. Transl Gastroenterol Hepatol. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Proposed mechanism on the interaction between SOAT1 and HCC development. It is hypothesized that increased levels of SOAT1 leads to the formation of lipid droplets containing cholesterol esters (CE) that are then transported to the site of the tumor, interacting with the tumor microenvironment (stromal cells, cancer stem cells, immune cells) to promote increased cancer cell growth and migration leading to a worse overall survival. On the other hand, increased expression of SOAT1 may directly promote tumor cell growth via an autocrine manner.
See this image and copyright information in PMC

Comment on

  • Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma.
    Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J, Qian X, He F; Chinese Human Proteome Project (CNHPP) Consortium. Jiang Y, et al. Nature. 2019 Mar;567(7747):257-261. doi: 10.1038/s41586-019-0987-8. Epub 2019 Feb 27. Nature. 2019. PMID: 30814741

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