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Case Reports
. 2019 Oct;140(4):296-300.
doi: 10.1111/ane.13142. Epub 2019 Jul 8.

Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE)

Kyriakos Garganis  1 , Vasileios Kokkinos  1   2 , Basilios Zountsas  1 , Argirios Dinopoulos  3 , Roland Coras  4 , Ingmar Blümcke  4
Affiliations
Case Reports

Temporal lobe "plus" epilepsy associated with oligodendroglial hyperplasia (MOGHE)

Kyriakos Garganis et al. Acta Neurol Scand. 2019 Oct.

Abstract

Background: Mild malformation of cortical dysplasia (mMCD) with oligodendroglial hyperplasia (MOGHE) is an epilepsy-related pathologic entity highlighted in post-surgical specimens of frontal lobe epilepsy (FLE) patients.

Aims of the study: We present two temporal lobe epilepsy (TLE) cases with MOGHE and discuss clinical, neurophysiological, and neuroimaging features that may be indicative of surgical outcome.

Methods: We identified two cases with MOGHE out of 30 temporal lobe epilepsy (TLE) surgical patient cohort, whose pathological distribution spared the hippocampal structures.

Results: The TLE cases shared common features with the FLE series in terms of patient profiles, MRI findings and post-surgical outcome. TLE plus seizure semiology combined with extratemporal scalp electroencephalographic (EEG) and electrocorticographic (ECoG) epileptiform elements at a distance from the imaging lesion were suggestive of an underlying multifocal pathology.

Conclusions: MOGHE pathology has to be considered in the decision-making process for TLE epilepsy surgery when this constellation of features is met.

Keywords: MRI; epilepsy surgery; histopathology; mild malformation of cortical development with oligodendroglial hyperplasia; temporal lobe plus epilepsy.

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References

REFERENCES

    1. Blumcke I, Spreafico R, Haaker G, et al. Histopathological findings in brain tissue obtained during epilepsy surgery. N Eng J Med. 2017;377(17):1648-1656.
    1. Schurr J, Coras R, Roessler K, et al. Mild malformation of cortical development with oligodendoglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological entity. Brain Pathol. 2017;27(1):26-35.
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