Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery^{1

2

3}, Richard W Birkinshaw^{4

5}, Tamia Nguyen^{1

3}, Jia-Nan Gong^{4

5}, Ella R Thompson^{1

3}, Zhen Xu^{4

5}, David A Westerman^{1

2

3}, Peter E Czabotar^{4

5}, Michael Dickinson^{2

3}, David C S Huang^{4

5}, John F Seymour^{2

3}, Andrew W Roberts^{2

4

5

6

7}

Affiliations

¹ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.
² Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
³ Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
⁵ Department of Medical Biology, University of Melbourne, Melbourne, Australia.
⁶ Centre for Cancer Research, University of Melbourne, Melbourne, Australia.
⁷ Victorian Comprehensive Cancer Centre, Melbourne, Australia.

PMID: 31234236
DOI: 10.1111/bjh.16069

Case Reports

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery et al. Br J Haematol. 2019 Sep.

. 2019 Sep;186(6):e188-e191.

doi: 10.1111/bjh.16069. Epub 2019 Jun 24.

Authors

Affiliations

¹ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.
² Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
³ Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
⁵ Department of Medical Biology, University of Melbourne, Melbourne, Australia.
⁶ Centre for Cancer Research, University of Melbourne, Melbourne, Australia.
⁷ Victorian Comprehensive Cancer Centre, Melbourne, Australia.

PMID: 31234236
DOI: 10.1111/bjh.16069

No abstract available

Keywords: BCL2; genetic analysis; lymphomas.

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Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Affiliations

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Authors

Affiliations

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources