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Case Reports
. 2019 Jan-Dec:7:2324709619858643.
doi: 10.1177/2324709619858643.

A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Elvira Umyarova  1 , Sreedhar Adapa  2 , Srikanth Naramala  3 , Vijay Gayam  4 , Narothama Reddy Aeddula  5 , Venu Madhav Konala  6
Affiliations
Case Reports

A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Elvira Umyarova et al. J Investig Med High Impact Case Rep. 2019 Jan-Dec.

Abstract

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.

Keywords: MIPI; aseptic meningitis; mantle cell lymphoma.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Bone marrow: morphology suspicious for a lymphoproliferative disorder.
Figure 2.
Figure 2.
Bone marrow: CD20 staining.
Figure 3.
Figure 3.
Bone marrow: cyclin D1 staining.
See this image and copyright information in PMC

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