Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Sep 2;216(9):1969-1971.
doi: 10.1084/jem.20191002. Epub 2019 Jun 24.

The nature of human IL-6

Anne Puel  1   2 , Jean-Laurent Casanova  3   2   4   5   6
Affiliations
Comment

The nature of human IL-6

Anne Puel et al. J Exp Med. .

Abstract

Countless functions have been attributed experimentally to IL-6. In this issue of JEM, Spencer et al. (https://doi.org/10.1084/jem.20190344) reveal essential, nonredundant functions of human IL-6. Patients with genetic deficiencies of the IL-6 receptor suffer from "hyper IgE syndrome."

PubMed Disclaimer

Figures

None
Insights from Anne Puel and Jean-Laurent Casanova.
See this image and copyright information in PMC

Comment on

  • Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
    Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED. Spencer S, et al. J Exp Med. 2019 Sep 2;216(9):1986-1998. doi: 10.1084/jem.20190344. Epub 2019 Jun 24. J Exp Med. 2019. PMID: 31235509 Free PMC article.

References

    1. Béziat V., et al. . 2018. Sci. Immunol. 3:eaat4956 10.1126/sciimmunol.aat4956 - DOI - PMC - PubMed
    1. Boisson-Dupuis S., et al. . 2018. Sci. Immunol. 3:eaau8714 10.1126/sciimmunol.aau8714 - DOI - PMC - PubMed
    1. Casanova J.L., et al. . 2011. Annu. Rev. Immunol. 29:447–491. 10.1146/annurev-immunol-030409-101335 - DOI - PubMed
    1. Casanova J.L., et al. . 2014. J. Exp. Med. 211:2137–2149. 10.1084/jem.20140520 - DOI - PMC - PubMed
    1. Davis M.M., and Brodin P.. 2018. Annu. Rev. Immunol. 36:843–864. 10.1146/annurev-immunol-042617-053206 - DOI - PMC - PubMed