This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2019 Jul;22(7):1043-1045.

doi: 10.1038/s41593-019-0435-y.

A traffic jam leads to Lewy bodies

Tim Bartels^{1

2}

Affiliations

Affiliations

¹ Dementia Research Institute, University College London, London, United Kingdom. t.bartels@ucl.ac.uk.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. t.bartels@ucl.ac.uk.

PMID: 31235905
DOI: 10.1038/s41593-019-0435-y

Comment

A traffic jam leads to Lewy bodies

Tim Bartels. Nat Neurosci. 2019 Jul.

. 2019 Jul;22(7):1043-1045.

doi: 10.1038/s41593-019-0435-y.

Author

Tim Bartels^{1

2}

Affiliations

¹ Dementia Research Institute, University College London, London, United Kingdom. t.bartels@ucl.ac.uk.
² Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. t.bartels@ucl.ac.uk.

PMID: 31235905
DOI: 10.1038/s41593-019-0435-y

No abstract available

PubMed Disclaimer

Comment on

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME. Shahmoradian SH, et al. Nat Neurosci. 2019 Jul;22(7):1099-1109. doi: 10.1038/s41593-019-0423-2. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235907

Similar articles

In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies.
Gai WP, Yuan HX, Li XQ, Power JT, Blumbergs PC, Jensen PH. Gai WP, et al. Exp Neurol. 2000 Dec;166(2):324-33. doi: 10.1006/exnr.2000.7527. Exp Neurol. 2000. PMID: 11085897
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.
Sandmann-Keil D, Braak H, Okochi M, Haass C, Braak E. Sandmann-Keil D, et al. Acta Neuropathol. 1999 Nov;98(5):461-4. doi: 10.1007/s004010051110. Acta Neuropathol. 1999. PMID: 10541868
Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro.
Welander H, Bontha SV, Näsström T, Karlsson M, Nikolajeff F, Danzer K, Kostka M, Kalimo H, Lannfelt L, Ingelsson M, Bergström J. Welander H, et al. Biochem Biophys Res Commun. 2011 Aug 19;412(1):32-8. doi: 10.1016/j.bbrc.2011.07.027. Epub 2011 Jul 21. Biochem Biophys Res Commun. 2011. PMID: 21798243
Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?
Chartier S, Duyckaerts C. Chartier S, et al. Cell Tissue Res. 2018 Jul;373(1):149-160. doi: 10.1007/s00441-018-2854-6. Epub 2018 Jun 5. Cell Tissue Res. 2018. PMID: 29869713 Review.
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.
Spillantini MG, Goedert M. Spillantini MG, et al. Ann N Y Acad Sci. 2000;920:16-27. doi: 10.1111/j.1749-6632.2000.tb06900.x. Ann N Y Acad Sci. 2000. PMID: 11193145 Review.

See all similar articles

Cited by

In situ architecture of neuronal α-Synuclein inclusions.
Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R. Trinkaus VA, et al. Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. Nat Commun. 2021. PMID: 33854052 Free PMC article.
Can the lack of fibrillar form of alpha-synuclein in Lewy bodies be explained by its catalytic activity?
Kuznetsov IA, Kuznetsov AV. Kuznetsov IA, et al. Math Biosci. 2022 Feb;344:108754. doi: 10.1016/j.mbs.2021.108754. Epub 2021 Dec 7. Math Biosci. 2022. PMID: 34890628 Free PMC article.
Parkinson's disease: proteinopathy or lipidopathy?
Fanning S, Selkoe D, Dettmer U. Fanning S, et al. NPJ Parkinsons Dis. 2020 Jan 3;6:3. doi: 10.1038/s41531-019-0103-7. eCollection 2020. NPJ Parkinsons Dis. 2020. PMID: 31909184 Free PMC article. Review.
Vesicle trafficking and lipid metabolism in synucleinopathy.
Fanning S, Selkoe D, Dettmer U. Fanning S, et al. Acta Neuropathol. 2021 Apr;141(4):491-510. doi: 10.1007/s00401-020-02177-z. Epub 2020 Jun 30. Acta Neuropathol. 2021. PMID: 32607605 Free PMC article. Review.
Cerium Oxide Nanoparticles Rescue α-Synuclein-Induced Toxicity in a Yeast Model of Parkinson's Disease.
Ruotolo R, De Giorgio G, Minato I, Bianchi MG, Bussolati O, Marmiroli N. Ruotolo R, et al. Nanomaterials (Basel). 2020 Jan 29;10(2):235. doi: 10.3390/nano10020235. Nanomaterials (Basel). 2020. PMID: 32013138 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Medical
- MedlinePlus Health Information