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. 2018 Dec 25;53(Suppl 1):S32-S44.
doi: 10.5152/TurkPediatriArs.2018.01805. eCollection 2018.

Turkish Neonatal Society Guideline on neonatal encephalopathy

Mete Akisu  1 , Abdullah Kumral  2 , Fuat Emre Canpolat  3
Affiliations

Turkish Neonatal Society Guideline on neonatal encephalopathy

Mete Akisu et al. Turk Pediatri Ars. .

Abstract
in English, Turkish

Neonatal encephalopathy is a major cause of neonatal mortality and morbidity. Therapeutic hypothermia is standard treatment for newborns at 35 weeks of gestation or more with intrapartum hypoxia-related neonatal encephalopathy. Term and late preterm infants with moderate-to-severe encephalopathy show improved survival and neurodevelopmental outcomes at 18 months of age after therapeutic hypothermia. Therapeutic hypothermia can increase survival without increasing major disability. Neonates with severe neonatal encephalopathy remain at risk of death or severe neurodevelopmental impairment. This guideline was prepared by the Turkish Neonatal Society to standardize the management of neonatal encephalopathy throughout the country.

Yenidoğan ensefalopatisi yenidoğanlarda ölüm ve morbiditenin en önemli nedenlerinden biridir. Terapötik hipotermi, gebeliğin 35. haftasından sonra doğmuş yenidoğanlar için standart tedavi olup, doğum ve sonrasında gelişen hipoksi ile ilişkili yenidoğan ensefalopatisinde kullanılmaktadır. Terapötik hipotermi tedavisinden sonra, orta ve ağır ensefalopatili term ve geç preterm doğmuş bebeklerin, 18 ayda sağkalım ve nörogelişimsel sonuçlarının iyileştiği görülmektedir. Terapötik hipotermi, sakatlığı arttırmaksızın yaşam kalitesini arttırabilir. Şiddetli yenidoğan ensefalopatisi geçiren yenidoğanlar, ölüm riski altındadır ya da ciddi nörogelişimsel bozulmaya eğilimlidir. Bu rehber, Türk Neonatoloji Derneği tarafından, yenidoğan ensefalopatisi tedavisinin ülke çapında standartlaştırılması için hazırlanmıştır.

Keywords: Guideline; hypoxic ischemic encephalopathy; neonatal encephalopathy; therapeutic hypothermia.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Classification of “Amplitude integrated” EEG images
Figure 2
Figure 2
Diagram for management of seizures in hypoxic ischemic encephalopathy EEG: electroencephalograph
Figure 3
Figure 3
Summarized algorithm of approach in hypoxic ischemic encephalopathy aEEG: amplitude-integrated EEG; EEG: electroencephalography; INO: inhaled nitric oxide; HFO: high-frequency ventilation; MRI: magnetic resonance imaging; USG: ultrasonography
See this image and copyright information in PMC

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