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Meta-Analysis
. 2019 May 19:2019:2153170.
doi: 10.1155/2019/2153170. eCollection 2019.

Factors Affecting the Survival of Patients with Oligometastatic Non-Small-Cell Lung Cancer: A Meta-Analysis

Yu Shi  1   2 , Jianxin Yang  3 , Ninghua Yao  2 , Minghai Shao  1   4 , Wenxiu Ding  1   5 , Wanrong Jiang  1   6 , Xinchen Sun  1
Affiliations
Meta-Analysis

Factors Affecting the Survival of Patients with Oligometastatic Non-Small-Cell Lung Cancer: A Meta-Analysis

Yu Shi et al. Can Respir J. .

Abstract

Background: The aim was to investigate the potential factors related with overall survival of oligometastatic non-small-cell lung cancer (NSCLC) patients.

Methods: A literature search was conducted in databases including PubMed, Embase, and Cochrane library up to March 2017. The hazard radio (HR) as well as the corresponding 95% confidence interval (CI) were calculated, and all the statistics analysis was performed by the R 3.12. Heterogeneity was analyzed using I-squared and Cochran Q tests. Furthermore, sensitivity analysis was performed to evaluate the stability of results.

Results: In total, 6 articles were included in the meta-analysis. Nodal status was significantly correlated with the overall survival rate of NSCLC oligometastatic patients (HR: 1.69, 95% CI: 1.23-2.32, Z=3.20, P=0.001). No significant relationship was found between overall survival rate of NSCLC oligometastatic patients and the indicators including sex, stage, smoker, age, and histology. Notably, sensitivity analysis on data evaluating relationship between patients survival and the stage and histology showed that results were reversed after removing one of the studies.

Conclusions: Nodal status might be associated with the overall survival of oligometastatic NSCLC patients.

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Figures

Figure 1
Figure 1
Flow diagram of the study selection process.
Figure 2
Figure 2
Meta-analysis for the association of survival of oligometastatic non-small-cell lung cancer patients with sex (a), stage (b), nodal status (c), smoke (d), age (e), and histology (f).
Figure 3
Figure 3
Sensitivity analysis for the association of survival of oligometastatic non-small-cell lung cancer patients with sex (a), stage (b), nodal status (c), smoke (d), age (e), and histology (f).
See this image and copyright information in PMC

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References

    1. Komaki R., Tsao A. S., Mehran R. J. 60 Years of Survival Outcomes at the University of Texas MD Anderson Cancer Center. New York, NY, USA: Springer; 2012. Non-small cell lung cancer; pp. 45–62.
    1. Torre L. A., Bray F., Siegel R. L., Ferlay J., Lortet-Tieulent J., Jemal A. Global cancer statistic, 2012. Ca A Cancer Journal for Clinicians. 2015;65(2):87–108. doi: 10.3322/caac.21262. - DOI - PubMed
    1. D’Addario G., Früh M., Reck M., et al. Metastatic non-small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2016;21(5):v116–v119. doi: 10.1093/annonc/mdq189. - DOI - PubMed
    1. Sørensen J. B., Hansen H. H., Hansen M., Dombernowsky P. Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis. Journal of Clinical Oncology. 1988;6(9):1474–1480. doi: 10.1200/JCO.1988.6.9.1474. - DOI - PubMed
    1. Johung K. L., Yeh N., Desai N. B., et al. Extended survival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis. Journal of Clinical Oncology. 2016;34(2):123–129. doi: 10.1200/jco.2015.62.0138. - DOI - PMC - PubMed

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