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Review
. 2019 May;8(Suppl 2):S192-S197.
doi: 10.21037/tau.2018.10.14.

Cytomegalovirus infection in kidney allografts: a review of literature

Giuliano Ferreira Morgantetti  1 , Marcelo Luiz Balancin  2 , Guilherme Alencar de Medeiros  1 , Márcio Dantas  1 , Gyl Eanes Barros Silva  3
Affiliations
Review

Cytomegalovirus infection in kidney allografts: a review of literature

Giuliano Ferreira Morgantetti et al. Transl Androl Urol. 2019 May.

Abstract

Cytomegalovirus (CMV) is an important cause of renal transplantation complications. It can cause different syndromes or end-organ diseases that can lead to unfavourable clinical outcomes and kidney allograft dysfunction. Although well documented as a systemic disease on renal transplant patients, affecting non-renal tissue, as gastrointestinal and respiratory tract, few cases have been reported in English-language indexed journals involving renal allograft lesions secondary to CMV. As an important differential diagnosis and etiological agent to acute and chronic rejection, the possibility of CMV kidney direct infection needs prompt recognition for effective treatment. In this paper, we will review the current literature about CMV nephritis and discuss the findings from each case report.

Keywords: Cytomegalovirus (CMV); cytomegalovirus kidney transplant; cytomegalovirus nephritis; kidney pathology; transplantation pathology.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Cowdry type A nuclear inclusion in CMV affected epithelial and endothelial cells, illustrated by eosinophilic intranuclear inclusion of hyaline material; binucleations may lead to the “owls eyes” characteristics (A, arrow). (A, endothelium predominant; B, epithelial compartment predominant; H&E, ×400) (from author’s archives). CMV, cytomegalovirus.
See this image and copyright information in PMC

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