Oral antibiotics for neonatal infections: a systematic review and meta-analysis

Abstract

Background: Worldwide many neonates suffer from bacterial infections. Adequate treatment is important but is associated with prolonged hospitalization for intravenous administration. In older children, oral switch therapy has been proven effective and safe for several indications and is now standard care.

Objectives: To evaluate the currently available evidence on pharmacokinetics, safety and efficacy of oral antibiotics and oral switch therapy in neonates (0-28 days old).

Methods: We performed systematic searches in Medline, Embase.com, Cochrane, Google Scholar and Web of Science. Studies were eligible if they described the use of oral antibiotics in neonates (0-28 days old), including antibiotic switch studies and pharmacological studies.

Results: Thirty-one studies met the inclusion criteria. Compared with parenteral administration, oral antibiotics generally reach their maximum concentration later and have a lower bioavailability, but in the majority of cases adequate serum levels for bacterial killing are reached. Furthermore, studies on efficacy of oral antibiotics showed equal relapse rates (OR 0.95; 95% CI 0.79-1.16; I2 0%) or mortality (OR 1.11; 95% CI 0.72-1.72; I2 0%). Moreover, a reduction in hospital stay was observed.

Conclusions: Oral antibiotics administered to neonates are absorbed and result in adequate serum levels, judged by MICs of relevant pathogens, over time. Efficacy studies are promising but robust evidence is lacking, most importantly because in many cases clinical efficacy and safety are not properly addressed. Early oral antibiotic switch therapy in neonates could be beneficial for both families and healthcare systems. There is a need for additional well-designed trials in different settings.

Figure 1.

Study selection.

Figure 2.

(a) Forest plot comparing treatment failure of reference treatment (penicillin/gentamicin im for 7 days) with switch regimen (penicillin/gentamicin im for 2 days followed by oral amoxicillin for 5 days). The regimens used are further described in Table 3. (b) Forest plot comparing mortality of reference treatment (penicillin/gentamicin im for 7 days) with switch regimen (penicillin/gentamicin im for 2 days followed by oral amoxicillin for 5 days). The regimens used are further described in Table 3. PEN, penicillin; GEN, gentamicin.