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Meta-Analysis
. 2019 Sep;86(3):468-471.
doi: 10.1002/ana.25534. Epub 2019 Jul 3.

Smoking and stroke: A mendelian randomization study

Susanna C Larsson  1   2 , Stephen Burgess  3   4 , Karl Michaëlsson  2
Affiliations
Meta-Analysis

Smoking and stroke: A mendelian randomization study

Susanna C Larsson et al. Ann Neurol. 2019 Sep.

Abstract

We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630 noncases, and 1,545 cases of intracerebral hemorrhage and 1,481 noncases. Genetic predisposition to smoking initiation (ever smoking regularly), based on up to 372 single-nucleotide polymorphisms, was statistically significantly positively associated with any ischemic stroke, large artery stroke, and small vessel stroke but not cardioembolic stroke or intracerebral hemorrhage. This study provides genetic support for a causal association of smoking with ischemic stroke, particularly large artery and small vessel stroke. ANN NEUROL 2019;86:468-471.

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Conflict of interest statement

Nothing to report.

Figures

Figure 1
Figure 1
Associations of genetic predisposition to smoking initiation with ischemic stroke and its subtypes and intracerebral hemorrhage. Odds ratios are expressed per unit increase in log odds of ever smoking regularly (smoking initiation). Estimates were obtained using the inverse variance‐weighted method under a random‐effects model. CI = confidence interval; OR = odds ratio.
Figure 2
Figure 2
Associations of genetically predicted lifetime smoking index with ischemic stroke and its subtypes and intracerebral hemorrhage. Odds ratios are expressed per 1 standard deviation increase of the lifetime smoking index. Estimates were obtained using the inverse variance‐weighted method under a random‐effects model. CI = confidence interval; OR = odds ratio.
See this image and copyright information in PMC

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