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Review
. 2020 Jan;126(1):9-20.
doi: 10.1111/bcpt.13282. Epub 2019 Jul 19.

Monoterpenes modulating autophagy: A review study

Milad Ashrafizadeh  1   2 , Zahra Ahmadi  3 , Reza Mohammadinejad  4 , Nasim Kaviyani  5 , Shima Tavakol  6
Affiliations
Free article
Review

Monoterpenes modulating autophagy: A review study

Milad Ashrafizadeh et al. Basic Clin Pharmacol Toxicol. 2020 Jan.
Free article

Abstract

From the beginning of the 21st century, much attention has been made towards the medicinal herbs due to their low side effects and valuable biological activities. Among them, terpenes comprise a large group of naturally occurring chemical compounds that are considered as main components of flavours, antifeedants and pheromones. Monoterpenes have demonstrated a favourable profile as compounds that have antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective and anti-tumour activities. On the other hand, autophagy is a 'self-digestion' mechanism which plays a remarkable role in a number of pathological conditions such as cancer, ageing, metabolic disorders and infection. Also, autophagy is considered as a stress adaptor that may lead to apoptotic cell death under severe and sustained stress. Autophagy modulation is a promising strategy in cancer treatment, and a variety of drugs have been designed in line with this strategy. In the present MiniReview, we discuss the effects of monoterpenes on autophagy and its relationship with therapeutic impacts of monoterpenes.

Keywords: autophagy; cell stress; medicinal herbs; monoterpenes; programmed cell death.

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References

REFERENCES

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