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. 2020 Oct;26(11):1437-1440.
doi: 10.1177/1352458519860304. Epub 2019 Jun 25.

Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia

Lindsey B De Lott  1 , Samantha Zerafa  2 , Kerby Shedden  3 , Galit Levi Dunietz  1 , Michelle Earley  4 , Benjamin M Segal  1 , Tiffany J Braley  1
Affiliations

Multiple sclerosis relapse risk in the postoperative period: Effects of invasive surgery and anesthesia

Lindsey B De Lott et al. Mult Scler. 2020 Oct.

Abstract

Background: Postoperative multiple sclerosis (MS) relapses are a concern among patients and providers.

Objective: To determine whether MS relapse risk is higher postoperatively.

Methods: Data were extracted from medical records of MS patients undergoing surgery at a tertiary center (2000-2016). Conditional logistic regression estimated within-patient unadjusted and age-adjusted odds of postoperative versus preoperative relapse.

Results: Among 281 patients and 609 surgeries, 12 postoperative relapses were identified. The odds of postoperative versus preoperative relapse in unadjusted (odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.18-1.79; p = 0.33) or age-adjusted models (OR = 0.66, 95% CI = 0.20-2.16; p = 0.49) were not increased.

Conclusions: Surgery/anesthesia exposure did not increase postoperative relapse risk. These findings require confirmation in larger studies.

Keywords: Anesthesia; logistic models; multiple sclerosis; postoperative period; preoperative period; retrospective studies.

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