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Review
. 2019 Sep;33(3):681-692.
doi: 10.1016/j.idc.2019.05.003. Epub 2019 Jun 22.

Initial Antiretroviral Therapy in an Integrase Inhibitor Era: Can We Do Better?

Sean G Kelly  1 , Mary Clare Masters  2 , Babafemi O Taiwo  2
Affiliations
Review

Initial Antiretroviral Therapy in an Integrase Inhibitor Era: Can We Do Better?

Sean G Kelly et al. Infect Dis Clin North Am. 2019 Sep.

Abstract

With the second-generation integrase inhibitors (dolutegravir and bictegravir) extending the attributes of earlier integrase inhibitors, three-drug regimens containing integrase inhibitors plus two nucleos(t)ide reverse transcriptase inhibitors are now widely recommended for first-line (initial) treatment of human immunodeficiency virus-1 infection. Led by dolutegravir plus lamivudine, two-drug therapy is emerging as a way to reduce antiretroviral therapy cost and adverse effects without compromising treatment options should virologic failure occur. Initial two-drug therapy has limitations, including the relative incompatibility with the coemerging concept of same-day antiretroviral therapy initiation.

Keywords: Bictegravir; Dolutegravir; Dual therapy; Integrase stand transfer inhibitors; Rapid start.

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Conflict of interest statement

Disclosure Statement: B.O. Taiwo has served as a consultant for ViiV, GSK, Gilead, Merck, and Janssen; and received research funding through Northwestern University from ViiV. S.G. Kelly and M.C. Masters have no potential conflicts of interest.

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