The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism
Affiliations
- PMID: 3123944
Item in Clipboard
The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism
NIDA Res Monogr.
1986.
Abstract
The tripeptide Tyr-Gly-Gly (YGG) was established as an endogenous constituent in rat brain. Its origin from enkephalin neurons is suggested by its regional distribution paralleling that of (Met5)-enkephalin (YGGFM), its decrease following kainate-induced ablation of the striato-pallidal neurons and its enhanced formation following depolarization of pallidal slices. Enkephalinase (EC 3.4.24.11) is selectively responsible for endogenous YGG formation in vitro and in vivo.
Similar articles
-
The endogenous tripeptide Tyr-Gly-Gly as a possible metabolite of opioid peptides in rat brain: identification, regional distribution, effects of lesions and formation in depolarized slices.Peptides. 1986 Jul-Aug;7(4):669-77. doi: 10.1016/0196-9781(86)90043-4. Peptides. 1986. PMID: 3532054
-
Dopaminergic regulation of enkephalin release.J Neurochem. 1991 Apr;56(4):1368-75. doi: 10.1111/j.1471-4159.1991.tb11434.x. J Neurochem. 1991. PMID: 1672147
-
Steady-state level and turnover rate of the tripeptide Tyr-Gly-Gly as indexes of striatal enkephalin release in vivo and their reduction during pentobarbital anesthesia.Proc Natl Acad Sci U S A. 1986 Aug;83(16):6226-30. doi: 10.1073/pnas.83.16.6226. Proc Natl Acad Sci U S A. 1986. PMID: 3526354 Free PMC article.
-
[Enkephalin and endogenous enkephalinase inhibitor].Seikagaku. 1994 Jan;66(1):57-60. Seikagaku. 1994. PMID: 8120427 Review. Japanese. No abstract available.
-
Commentary. The in vivo fate of brain oligopeptides.Biochem Pharmacol. 1975 Nov 15;24(22):2025-30. doi: 10.1016/0006-2952(75)90098-2. Biochem Pharmacol. 1975. PMID: 1108882 Review. No abstract available.