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. 1986:75:275-8.

Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly

C Llorens-Cortes  1 , C Gros, J C Schwartz
Affiliations
  • PMID: 3123945

Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly

C Llorens-Cortes et al. NIDA Res Monogr. 1986.

Abstract

The tripeptide Tyr-Gly-Gly (YGG), an extraneuronal metabolite of opioid peptides (OP) derived from proenkephalin A is in a highly dynamic state in mouse striatum. Inhibition of its synthesis by Thiorphan reduced its levels with a t 1/2 of 12 min. Inhibition of its degradation by bestatin elicited its rapid accumulation consistent with a t 1/2 of enkephalins in the one-hour range. Pentobarbital anesthesia markedly reduced its steady state level and turnover rates.

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