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Review
. 2019 Jul;24(4):276-290.
doi: 10.1093/pch/pxz056. Epub 2019 Jun 21.

Neuroprotection from acute brain injury in preterm infants

[Article in English, French]
Michelle Ryan  1 , Thierry Lacaze-Masmonteil  1 , Khorshid Mohammad  1
Affiliations
Review

Neuroprotection from acute brain injury in preterm infants

[Article in English, French]
Michelle Ryan et al. Paediatr Child Health. 2019 Jul.

Abstract

Infants born at ≤32+6 weeks gestation are at higher risk for intracranial ischemic and hemorrhagic injuries, which often occur in the first 72 hours postbirth. Antenatal strategies to reduce the incidence of acute brain injuries include administering maternal corticosteroids and prompt antibiotic treatment for chorioamnionitis. Perinatal strategies include delivery within a tertiary centre, delayed cord clamping, and preventing hypothermia. Postnatal strategies include empiric treatment with antibiotics when chorioamnionitis is suspected, the cautious use of inotropes, the avoidance of blood PCO2 fluctuation, and neutral head positioning. Clinicians should be aware of the policies and procedures that, especially when combined, can provide neuroprotection for preterm infants.

Keywords: Acute brain injury; Infant; Intraventricular hemorrhage; Neuroprotection; Neuroprotective strategies; Premature.

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References

    1. Canadian Neonatal Network. Annual Report, 2017 http://www.canadianneonatalnetwork.org/Portal/LinkClick.aspx?fileticket=... (Accessed February 1, 2018).
    1. Resch B, Resch E, Maurer U, Muller W. Cystic periventricular leukomalacia: A declining source of severe neurodevelopmental impairment in preterm infants? Pediatr Res 2011;70(S5):202.
    1. Back SA, Rivkees SA. Emerging concepts in periventricular white matter injury. Semin Perinatol 2004;28(6):405–14. - PubMed
    1. Synnes A, Luu TM, Moddemann D, et al. . Determinants of developmental outcomes in a very preterm Canadian cohort. Arch Dis Child Fetal Neonatal Ed 2017;102(3):F235–F34. - PubMed
    1. Volpe JJ. Neurology of the Newborn, 5th edn. Oxford, UK: Elsevier Health Sciences, 2008.