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Review
. 2019;21(1):41-44.

Symptomatic Rosai-Dorfman Disease Presenting as Isolated Bilateral Perinephric Infiltration

Daniel J Kmetz  1 , Bryant Van Leeuwen  1 , Dennis Bentley  1
Affiliations
Review

Symptomatic Rosai-Dorfman Disease Presenting as Isolated Bilateral Perinephric Infiltration

Daniel J Kmetz et al. Rev Urol. 2019.

Abstract

This case explores a rare initial presentation of Rosai-Dorfman disease isolated to the peri-renal space. Also described as sinus histiocytosis with massive lymphadenopathy, Rosai-Dorfman disease is non-neoplastic and most often presents with massive cervical lymphadenopathy, but the disease can affect any organ system. Not often considered by those in the urology community or found in urology journals, this report reviews a clinical presentation of Rosai-Dorfman disease affecting bilateral kidneys and the fundamental histopathology needed for its diagnosis.

Keywords: Rosai-Dorfman disease; Sinus histiocytosis with massive lymphadenopathy (SHML).

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Figures

Figure 1
Figure 1
CT scan revealed bilateral perinephric soft tissue masses encasing both kidneys, with the greatest on the left side measuring 12 cm × 11 cm × 22 cm.
Figure 2
Figure 2
CT scan revealed bilateral perinephric soft tissue masses encasing both kidneys, with the greatest on the left side measuring 12 cm × 11 cm × 22 cm.
Figure 3
Figure 3
Tissue biopsy showing predominant lymphocyte infiltration. Some histocytes have voluminous and granular cytoplasmic content.
See this image and copyright information in PMC

References

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