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Multicenter Study
. 2019 Sep;10(3):397-422.
doi: 10.1007/s13239-019-00422-5. Epub 2019 Jun 25.

In-Vitro Pulsatile Flow Testing of Prosthetic Heart Valves: A Round-Robin Study by the ISO Cardiac Valves Working Group

Changfu Wu  1 , Neelakantan Saikrishnan  2   3 , Aaron J Chalekian  4 , Rob Fraser  5 , Ornella Ieropoli  6 , Stephen M Retta  7 , Russell Joseph  8 , Shouyan Lee  9 , Salvador Marquez  8 , David Mester  10 , Ning Pan  11 , Sepehr Vatanpour  12 , Craig Weinberg  13 , Ulrich Steinseifer  14
Affiliations
Multicenter Study

In-Vitro Pulsatile Flow Testing of Prosthetic Heart Valves: A Round-Robin Study by the ISO Cardiac Valves Working Group

Changfu Wu et al. Cardiovasc Eng Technol. 2019 Sep.

Abstract

Purpose: Hydrodynamic performance testing is one of the core in vitro assessments required by the ISO 5840 series of standards for all prosthetic heart valves. A round-robin study carried out in 2005 in accordance with ISO 5840:2005 revealed significant variabilities in prosthetic heart valve hydrodynamic performance measurements among the participating laboratories. In order to re-examine the inter-laboratory variability based on the "state-of-the-art" under ISO 5840-1 and 5840-2:2015, the ISO Cardiac Valve Working Groups decided in 2016 to repeat the round-robin study.

Methods: A total of 13 international laboratories participated in the study. The test valves were chosen to be the St. Jude Medical Masters Series mechanical valves (19 mm aortic, 25 mm aortic, 25 mm mitral, and 31 mm mitral), which were circulated among the laboratories. The testing was conducted according to a common test run sequence, with prespecified flow conditions.

Results: The study revealed improved, yet still significant variability among different laboratories as compared to the 2005 study. The coefficient of variation ranged from 7.7 to 21.6% for the effective orifice area, from 10.1 to 32.8% for the total regurgitant fraction, and from 14.7 to 45.5% for the mean transvalvular pressure gradient.

Conclusions: The study revealed the ambiguities in the current versions of the ISO 5840 series of standards and the shortcomings of some participating laboratories. This information has allowed the ISO Working Group to incorporate additional clarifying language into the ISO 5840-1, -2, and -3 standards that are currently under revision to improve in vitro assessments. The results presented here can also be used by the testing laboratories to benchmark pulse duplicator systems and to train and certify testing personnel.

Keywords: Effective orifice area; Hydrodynamic performance testing; Mean pressure gradient; Prosthetic heart valves; Total regurgitant fraction; Waveform.

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Comment in

  • Editorial.
    Yoganathan AP, Dasi P. Yoganathan AP, et al. Cardiovasc Eng Technol. 2019 Sep;10(3):395-396. doi: 10.1007/s13239-019-00429-y. Cardiovasc Eng Technol. 2019. PMID: 31432452 No abstract available.

References

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