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. 2019 Jun;24(25):1900340.
doi: 10.2807/1560-7917.ES.2019.24.25.1900340.

Detection of plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from pork, Sichuan and Shandong Provinces, China, February 2019

Li Bai  1   2   3 , Pengcheng Du  3   4 , Yinju Du  5 , Honghu Sun  1   2   6 , Pei Zhang  1   2 , Yuping Wan  6 , Qi Lin  6 , Séamus Fanning  1   2   7 , Shenghui Cui  8 , Yongning Wu  1   2
Affiliations

Detection of plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from pork, Sichuan and Shandong Provinces, China, February 2019

Li Bai et al. Euro Surveill. 2019 Jun.

Abstract

The plasmid-mediated high-level tigecycline resistance gene, tet(X4), was detected in seven Escherichia coli isolates from pork in two Chinese provinces. Two isolates belonged to the epidemic spreading sequence type ST101. Tet(X4) was adjacent to ISVsa3 and concurrent with floR in all seven isolates. In addition to IncFIB, the replicon IncFII was found to be linked to tet(X4). This report follows a recent detection of tet(X3)/(X4) in E. coli from animals and humans in China.

Keywords: Escherichia coli; conjugative plasmid; tigecycline resistance.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
A heat-map showing the comparison of the Escherichia coli donors and the resultant transconjugants, characterised on the basis of their origins, plasmid profiles; ESBL-types; replicon types; susceptibility profiles and MIC of tigecycline, China, February 2019
Figure 2
Figure 2
Gene alignments of the tet(X4) transposon in isolates from this study with that of p47EC reported by He et al., China, February, 2019
See this image and copyright information in PMC

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