Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jan;85(2):529-33.
doi: 10.1073/pnas.85.2.529.

Site of unequal sister chromatid exchange contains a potential Z-DNA-forming tract

A Weinreb  1 , D R Katzenberg, G L Gilmore, B K Birshtein
Affiliations

Site of unequal sister chromatid exchange contains a potential Z-DNA-forming tract

A Weinreb et al. Proc Natl Acad Sci U S A. 1988 Jan.

Abstract

Previous studies from this laboratory have provided evidence that the duplication of the IgG2a heavy chain constant region gene (C gamma 2a) in the murine myeloma cell line MPC-11 occurred via unequal sister chromatid exchange. We now report the determination of the DNA sequences of the germ-line regions in which this exchange has occurred. The two donor sequences have long regions of virtual identity. Furthermore, both chromatids contain stretches of T-C and T-G dinucleotides; the latter has the potential to form Z-DNA. Localization of the actual breakpoints via genomic Southern blot analysis suggests a novel mechanism for the recombination and strongly implicates the simple sequence in the process.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1982 Jul 1;298(5869):82-4 - PubMed
    1. Mol Cell Biol. 1986 Nov;6(11):3934-47 - PubMed
    1. Cell. 1984 Mar;36(3):593-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7033-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Nov;82(22):7595-8 - PubMed

Publication types

Associated data