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. 2019 Aug 1;81(4):387-394.
doi: 10.1097/QAI.0000000000002050.

Incidence of AIDS-Related Kaposi Sarcoma in All 50 United States From 2000 to 2014

Donna L White  1   2   3   4   5 , Abiodun Oluyomi  4 , Kathryn Royse  2 , Yongquan Dong  2 , Harrison Nguyen  2 , Elaine Chang  2   6 , Peter Richardson  2 , Li Jiao  1   2   3   4   5 , Jose M Garcia  7   8 , Jennifer R Kramer  2   3   4 , Aaron P Thrift  4   9 , Elizabeth Chiao  2   3   4   10
Affiliations

Incidence of AIDS-Related Kaposi Sarcoma in All 50 United States From 2000 to 2014

Donna L White et al. J Acquir Immune Defic Syndr. .

Abstract

Background: Although declining rates of incident AIDS-related Kaposi sarcoma (KS) have been reported, KS incidence rates have noted race/ethnic, age, and geographic diversity. We performed a comprehensive assessment of recent secular trends in AIDS-related KS incidence in the United States.

Methods: We identified incident KS diagnosed in men aged 20-54 years (who comprise most AIDS-related KS in the United States) using the US Cancer Statistics registry data. Joinpoint analysis assessed for trends in age-adjusted incidence rates between 2000 and 2014 calculating average annual percentage changes (AAPCs) with 95% confidence intervals. Heat maps were generated to compare age-adjusted HIV incidence rates with KS incidence rates.

Results: Age-adjusted KS incidence rates nationwide decreased from 1.44/100,000 to 0.95/100,000 between 2000 and 2014. Observed rate changes varied across subgroups; eg, there were significant decreases in 30-44 years (AAPC = -5.4%), particularly in Whites and Blacks, significant increases among 20-29 years (AAPC = 2.7), primarily in Blacks, and stable rates among 45-54 years (AAPC = -0.03). In Southern United States, the incidence rates among Blacks did not significantly change. The states with highest average age-adjusted rates over the study period were Georgia (2.71/100,000), New York (2.16/100,000), California (2.02/100,000), Florida (1.90/100,000), and Texas (1.39/100,000), with significantly decreasing trends over time, except Georgia where rates increased (AAPC = 1.8).

Conclusions: Although KS incidence rates have decreased nationally, age, racial, and geographic disparities persist, including increasing risk among younger Black men and particularly elevated rates in some southern states and urban areas. Further research is needed to address racial and geographic AIDS-related KS disparities.

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Conflict of interest statement

Conflict of Interest: The authors declare no conflict of interest.

Figures

Figure 1A-1C.
Figure 1A-1C.
KS Incidence per 100,000 by Race/Ethnicity and Age-Group.
Figure 2.
Figure 2.
Age-adjusted KS Incidence Rates/100,000 in 5 states with largest number of KS cases.
Figure 3.
Figure 3.
Age-adjusted incidence rates of AIDS and KS in the U.S. across three year time periods.
Figure 4A-4C.
Figure 4A-4C.
KS Incidence per 100,000 by Race/Ethnicity and Region
See this image and copyright information in PMC

References

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Publication types

Supplementary concepts