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Review
. 2019 Aug 26;58(35):12286-12290.
doi: 10.1002/anie.201906692. Epub 2019 Jul 25.

Dual Photoredox/Nickel-Catalyzed Three-Component Carbofunctionalization of Alkenes

Andrés García-Domínguez  1 , Rahul Mondal  1 , Cristina Nevado  1
Affiliations
Review

Dual Photoredox/Nickel-Catalyzed Three-Component Carbofunctionalization of Alkenes

Andrés García-Domínguez et al. Angew Chem Int Ed Engl. .

Abstract

The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible-light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench-stable and easy-to-handle reagents, is operationally simple, and tolerates a wide variety of functional groups.

Keywords: alkenes; multicomponent reactions; nickel; photochemistry; reaction mechanisms.

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References

    1. For recent reviews, see:
    1. E. Merino, C. Nevado, Chem. Soc. Rev. 2014, 43, 6598;
    1. D. A. Petrone, J. Ye, M. Lautens, Chem. Rev. 2016, 116, 8003;
    1. R. K. Dhungana, S. KC, P. Basnet, R. Giri, Chem. Rec. 2018, 18, 1314;
    1. T. Fujihara, Y. Tsuji, Synthesis 2018, 50, 1737;

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