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Comment
. 2019 Jun 27;380(26):2584-2585.
doi: 10.1056/NEJMc1905282.

Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the GC Gene

Affiliations
Comment

Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the GC Gene

Anders H Berg et al. N Engl J Med. .
No abstract available

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Conflict of interest statement

Financial Disclosure Statement: Drs. Berg, Karumanchi, and Thadhani report being named coinventors on a patent (WO2014179737A3) on assays and methods of treatment relating to vitamin D insufficiency that is held by Massachusetts General Hospital. No other potential conflict of interest relevant to this letter was reported.

Figures

Figure 1:
Figure 1:
Vitamin D Binding-Protein and 25-Hydroxyvitamin D (25[OH]D) in Patients Admitted to an Intensive Care Unit (ICU). Panel A shows changes over time in levels of vitamin D binding-protein, total 25(OH)D, and directly measured free 25(OH)D in 3 patients admitted to an ICU. Panel B shows the Pearson’s correlation coefficient between serum total 25(OH)D and vitamin D-binding protein levels n 25 ICU patients at all time points sampled.

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References

    1. Meier U, Gressner O, Lammert F, Gressner AM. Gc-globulin: roles in response to injury. Clin Chem. 2006;52(7):1247–53. doi: 10.1373/clinchem.2005.065680. - DOI - PubMed
    1. Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG. Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels. J Clin Invest. 1986;78(3):748–52. doi: 10.1172/JCI112636. - DOI - PMC - PubMed
    1. Safadi FF, Thornton P, Magiera H, Hollis BW, Gentile M, Haddad JG, Liebhaber SA, Cooke NE. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest. 1999;103(2):239–51. doi: 10.1172/JCI5244. - DOI - PMC - PubMed
    1. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab. 2018;103(9):3278–88. doi: 10.1210/jc.2018-00295. - DOI - PMC - PubMed