Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun 25;20(12):3105.
doi: 10.3390/ijms20123105.

Adipose-Derived Mesenchymal Stem Cells: A Promising Tool in the Treatment of Musculoskeletal Diseases

Marta Torres-Torrillas  1 , Monica Rubio  2   3 , Elena Damia  4 , Belen Cuervo  5 , Ayla Del Romero  6 , Pau Peláez  7 , Deborah Chicharro  8 , Laura Miguel  9 , Joaquin J Sopena  10   11
Affiliations
Review

Adipose-Derived Mesenchymal Stem Cells: A Promising Tool in the Treatment of Musculoskeletal Diseases

Marta Torres-Torrillas et al. Int J Mol Sci. .

Abstract

Chronic musculoskeletal (MSK) pain is one of the most common medical complaints worldwide and musculoskeletal injuries have an enormous social and economical impact. Current pharmacological and surgical treatments aim to relief pain and restore function; however, unsatiscactory outcomes are commonly reported. In order to find an accurate treatment to such pathologies, over the last years, there has been a significantly increasing interest in cellular therapies, such as adipose-derived mesenchymal stem cells (AMSCs). These cells represent a relatively new strategy in regenerative medicine, with many potential applications, especially regarding MSK disorders, and preclinical and clinical studies have demonstrated their efficacy in muscle, tendon, bone and cartilage regeneration. Nevertheless, several worries about their safety and side effects at long-term remain unsolved. This article aims to review the current state of AMSCs therapy in the treatment of several MSK diseases and their clinical applications in veterinary and human medicine.

Keywords: adipose-derived mesenchymal stem cells; musculoskeletal diseases; regenerative medicine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Bashir J., Sherman A., Lee H., Kaplan L., Hare J.M. Mesenchymal Stem Cell Therapies in the Treatment of Musculoskeletal Diseases. PM&R. 2014;6:61–69. doi: 10.1016/j.pmrj.2013.05.007. - DOI - PubMed
    1. Couppe C., Hansen P., Kongsgaard M., Kovanen V., Suetta C., Aagaard P., Kjaer M., Magnusson S.P. Mechanical properties and collagen cross-linking of the patellar tendon in old and young men. J. Appl. Physiol. 2009;107:880–886. doi: 10.1152/japplphysiol.00291.2009. - DOI - PubMed
    1. Yelin E., Weinstein S., King T. The burden of musculoskeletal diseases in the United States. Semin. Arthritis Rheum. 2016;46:259–260. doi: 10.1016/j.semarthrit.2016.07.013. - DOI - PubMed
    1. Bianco P. “Mesenchymal” Stem Cells. Annu. Rev. Cell Dev. Biol. 2014;30:677–704. doi: 10.1146/annurev-cellbio-100913-013132. - DOI - PubMed
    1. Langrzyk A., Nowak W.N., Stepniewski J., Jazwa A., Florczyk-Soluch U., Jozkowicz A., Dulak J. Critical View on Mesenchymal Stromal Cells in Regenerative Medicine. Antioxid. Redox Signal. 2018;29:169–190. doi: 10.1089/ars.2017.7159. - DOI - PubMed

MeSH terms

LinkOut - more resources