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Comment
. 2019 Aug;9(8):OF8.
doi: 10.1158/2159-8290.CD-ND2019-008. Epub 2019 Jun 26.

Studies Show Clinical Utility of Precision Medicine

No authors listed
Comment

Studies Show Clinical Utility of Precision Medicine

No authors listed. Cancer Discov. 2019 Aug.

Abstract

As precision medicine has become increasingly important in cancer therapy, researchers have grappled with how to implement it in the clinic. Three studies demonstrate how different approaches to precision medicine-molecular profiling using individually customized combination therapy, RNA transcriptomics, and circulating tumor DNA sequencing-can be used to match patients to targeted treatments and trials.

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  • Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study.
    Rothwell DG, Ayub M, Cook N, Thistlethwaite F, Carter L, Dean E, Smith N, Villa S, Dransfield J, Clipson A, White D, Nessa K, Ferdous S, Howell M, Gupta A, Kilerci B, Mohan S, Frese K, Gulati S, Miller C, Jordan A, Eaton H, Hickson N, O'Brien C, Graham D, Kelly C, Aruketty S, Metcalf R, Chiramel J, Tinsley N, Vickers AJ, Kurup R, Frost H, Stevenson J, Southam S, Landers D, Wallace A, Marais R, Hughes AM, Brady G, Dive C, Krebs MG. Rothwell DG, et al. Nat Med. 2019 May;25(5):738-743. doi: 10.1038/s41591-019-0380-z. Epub 2019 Apr 22. Nat Med. 2019. PMID: 31011204
  • Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial.
    Rodon J, Soria JC, Berger R, Miller WH, Rubin E, Kugel A, Tsimberidou A, Saintigny P, Ackerstein A, Braña I, Loriot Y, Afshar M, Miller V, Wunder F, Bresson C, Martini JF, Raynaud J, Mendelsohn J, Batist G, Onn A, Tabernero J, Schilsky RL, Lazar V, Lee JJ, Kurzrock R. Rodon J, et al. Nat Med. 2019 May;25(5):751-758. doi: 10.1038/s41591-019-0424-4. Epub 2019 Apr 22. Nat Med. 2019. PMID: 31011205 Free PMC article. Clinical Trial.
  • Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study.
    Sicklick JK, Kato S, Okamura R, Schwaederle M, Hahn ME, Williams CB, De P, Krie A, Piccioni DE, Miller VA, Ross JS, Benson A, Webster J, Stephens PJ, Lee JJ, Fanta PT, Lippman SM, Leyland-Jones B, Kurzrock R. Sicklick JK, et al. Nat Med. 2019 May;25(5):744-750. doi: 10.1038/s41591-019-0407-5. Epub 2019 Apr 22. Nat Med. 2019. PMID: 31011206 Free PMC article. Clinical Trial.

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