Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan 15;59(2):153-161.
doi: 10.2169/internalmedicine.2521-18. Epub 2019 Jun 27.

Efficacy of Vonoprazan for Helicobacter pylori Eradication

Shu Kiyotoki  1 , Jun Nishikawa  2 , Isao Sakaida  3
Affiliations
Review

Efficacy of Vonoprazan for Helicobacter pylori Eradication

Shu Kiyotoki et al. Intern Med. .

Abstract

Helicobacter pylori can infect the gastric mucosa and cause chronic inflammation, resulting in various diseases, including gastric cancer. Eradication of H. pylori in all infected subjects is recommended; however, the number of H. pylori strains with antibiotic resistance has increased, and the eradication rate has decreased. Vonoprazan, a potassium-competitive acid blocker, produces a stronger acid-inhibitory effect than proton pump inhibitors (PPIs). The H. pylori eradication rate with vonoprazan was found to be higher than that with PPIs. The H. pylori eradication rate with vonoprazan-based triple therapy (vonoprazan, amoxicillin, and clarithromycin) was approximately 90% and had an incidence of adverse events similar to that of PPIs. We review the current situation of H. pylori eradication in Japan, the first country in which vonoprazan was made available.

Keywords: Helicobacter pylori; eradication; potassium-competitive acid blocker (P-CAB); proton pump inhibitor (PPI); vonoprazan.

PubMed Disclaimer

Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

References

    1. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1: 1273-1275, 1983. - PubMed
    1. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust 142: 436-439, 1985. - PubMed
    1. Morris A, Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 82: 192-199, 1987. - PubMed
    1. Asaka M, Kato M, Kudo M, et al. . Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: studies in asymptomatic Japanese adults. Helicobacter 1: 52-56, 1996. - PubMed
    1. Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter 12 (Suppl 2): 32-38, 2007. - PubMed

MeSH terms