Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2019 Oct;33(10):1821-1828.
doi: 10.1111/jdv.15729. Epub 2019 Jun 26.

2019 European guideline on the management of lymphogranuloma venereum

H J C de Vries  1   2 , B de Barbeyrac  3   4   5 , N H N de Vrieze  6 , J D Viset  2 , J A White  7 , M Vall-Mayans  8 , M Unemo  9
Affiliations
Practice Guideline

2019 European guideline on the management of lymphogranuloma venereum

H J C de Vries et al. J Eur Acad Dermatol Venereol. 2019 Oct.

Abstract

New or important issues in this updated version of the 2013 European guideline on the management of lymphogranuloma venereum (LGV): EPIDEMIOLOGY: Lymphogranuloma venereum continues to be endemic among European men who have sex with men (MSM) since 2003. Lymphogranuloma venereum infections in heterosexuals are extremely rare in Europe, and there is no evidence of transmission of LGV in the European heterosexual population.

Aetiology and transmission: Chlamydia trachomatis serovars/genovars L2b and L2 are the causative strains in the majority of cases in Europe.

Clinical features: Among MSM, about 25% of the anorectal LGV infections are asymptomatic. Genital infections among MSM are rare; the ratio of genital vs. anorectal LGV infections is 1 in 15.

Diagnosis: To diagnose LGV, a sample tested C. trachomatis positive with a commercial nucleic acid amplification test (NAAT) platform should be confirmed with an LGV discriminatory NAAT.

Treatment: Doxycycline 100 mg twice a day orally for 21 days is the recommended treatment for LGV. This same treatment is recommended also in asymptomatic patients and contacts of LGV patients. If another regimen is used, a test of cure (TOC) must be performed.

PubMed Disclaimer

References

    1. Vall-Mayans M, Caballero E, Sanz B. The emergence of lymphogranuloma venereum in Europe. Lancet 2009; 374: 356.
    1. de Vrieze NH, de Vries HJ. Lymphogranuloma venereum among men who have sex with men. An epidemiological and clinical review. Expert Rev Anti Infect Ther 2014; 12: 697-704.
    1. de Vrieze NH, van Rooijen M, Schim van der Loeff MF, de Vrieze HJ. Anorectal and inguinal lymphogranuloma venereum among men who have sex with men in Amsterdam, The Netherlands: trends over time, symptomatology and concurrent infections. Sex Transm Infect 2013; 89: 548-552.
    1. de Vrieze NHN, Versteeg B, Bruisten SM, van Rooijen MS, van der Helm JJ, de Vries HJC. low prevalence of urethral lymphogranuloma venereum infections among men who have sex with men: a prospective observational study, sexually transmitted infection clinic in Amsterdam, the Netherlands. Sex Transm Dis 2017; 44: 547-550.
    1. Desclaux A, Touati A, Neau D et al. Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study. Sex Transm Infect 2018; 94: 3-8.

Publication types

MeSH terms

Substances

LinkOut - more resources