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Review
. 2019 Feb;46(1):4-13.
doi: 10.1159/000495771. Epub 2019 Feb 5.

CAR-Expressing Natural Killer Cells for Cancer Retargeting

Stephan Kloess  1   2 , Anna Kretschmer  1 , Lilly Stahl  1 , Stephan Fricke  1 , Ulrike Koehl  1   3   2
Affiliations
Review

CAR-Expressing Natural Killer Cells for Cancer Retargeting

Stephan Kloess et al. Transfus Med Hemother. 2019 Feb.

Abstract

Since the approval in 2017 and the outstanding success of Kymriah® and Yescarta®, the number of clinical trials investigating the safety and efficacy of chimeric antigen receptor-modified autologous T cells has been constantly rising. Currently, more than 200 clinical trials are listed on clinicaltrial.gov. In contrast to CAR-T cells, natural killer (NK) cells can be used from allogeneic donors as an "off the shelf product" and provide alternative candidates for cancer retargeting. This review summarises preclinical results of CAR-engineered NK cells using both primary human NK cells and the cell line NK-92, and provides an overview about the first clinical CAR-NK cell studies targeting haematological malignancies and solid tumours, respectively.

Keywords: CAR-NK cell; Chimeric antigen receptor; Haematological malignancies; NK-92; Natural killer cells; Solid tumour.

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Figures

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Fig. 1
GMP-compliant manufacturing of CAR-T cells.
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