Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 18;9(11):3122-3133.
doi: 10.7150/thno.31918. eCollection 2019.

Bioengineering of Metal-organic Frameworks for Nanomedicine

Yuan Liu  1 , Yanli Zhao  2 , Xiaoyuan Chen  1
Affiliations
Review

Bioengineering of Metal-organic Frameworks for Nanomedicine

Yuan Liu et al. Theranostics. .

Abstract

Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.

Keywords: Metal-organic frameworks; drug delivery; photodynamic therapy; surface engineering.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Porous iron carboxylate MOFs for dry delivery. Reprinted with permission from ref. . Copyright (2010) Nature Publishing Group.
Figure 2
Figure 2
Free insulin loading to MOF NU-1000 and releasing in the presence of phosphate buffer saline. Pepsin which can digest insulin cannot access to the insulin that was stored in the porous MOF NU-1000 because of the large size of pepsin. Reprinted (adapted) with permission from ref. . Copyright (2018) American Chemical Society.
Figure 3
Figure 3
A) Cargo release from the duplex-capped MOF with different stimuli such as the DNase I, the nicking enzyme (Nt.BbvCI), the endonuclease (EcoRI), and the exonuclease (Exo III) as biocatalysts. Reprinted with permission from ref. Copyright (2018) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. B) ATP triggered drug release. Reprinted with permission from ref. Copyright (2017) WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Figure 4
Figure 4
Size-controlled synthesis of porphyrinic Zr-MOF (PCN-224) for photodynamic therapy. Reprinted (adapted) with permission from ref. . Copyright (2016) American Chemical Society.
Figure 5
Figure 5
A) Nucleic acid-MOF conjugation through covalent click reaction. Reprinted (adapted) with permission from ref. . Copyright (2014) American Chemical Society. B) Direct phosphate-terminal DNA conjugation to MOF. Reprinted (adapted) with permission from ref. . Copyright (2018), Royal Society of Chemistry.
See this image and copyright information in PMC

References

    1. Guo Z, Xiao C, Maligal-Ganesh RV, Zhou L, Goh TW, Li X. et al. Pt nanoclusters confined within metal-organic framework cavities for chemoselective cinnamaldehyde hydrogenation. ACS Catal. 2014;4:1340–8.
    1. Li Z, Peters AW, Platero-Prats AE, Liu J, Kung C-W, Noh H. et al. Fine-Tuning the Activity of Metal-Organic Framework-Supported Cobalt Catalysts for the Oxidative Dehydrogenation of Propane. J Am Chem Soc. 2017;139:15251–8. - PubMed
    1. Zhao M, Yuan K, Wang Y, Li G, Guo J, Gu L. et al. Metal-organic frameworks as selectivity regulators for hydrogenation reactions. Nature. 2016;539:76. - PubMed
    1. Li P, Moon S-Y, Guelta MA, Lin L, Gómez-Gualdrón DA, Snurr RQ. et al. Nanosizing a metal-organic framework enzyme carrier for accelerating nerve agent hydrolysis. ACS Nano. 2016;10:9174–82. - PubMed
    1. Shi W, Zhao X, Feng J, Liu J, Yang G, Wang G. et al. An Efficient, Visible-Light-Driven, Hydrogen Evolution Catalyst NiS/ZnxCd1-xS Nanocrystal Derived from a Metal-Organic Framework. Angew Chem Int Ed Engl. 2018;57:9790–4. - PubMed

Publication types

MeSH terms

Substances