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Case Reports
. 2019 Jun 14:28:100884.
doi: 10.1016/j.rmcr.2019.100884. eCollection 2019.

Acute thrombotic vascular events complicating influenza-associated pneumonia

Takashi Ishiguro  1 , Keisuke Matsuo  2 , Shinya Fujii  2 , Noboru Takayanagi  1
Affiliations
Case Reports

Acute thrombotic vascular events complicating influenza-associated pneumonia

Takashi Ishiguro et al. Respir Med Case Rep. .

Abstract

A 58-year-old man with previous myocardial infarction presented to our hospital with fever, cough, and dyspnea. PCR testing with nasopharyngeal swabs confirmed influenza virus infection, and enhanced computed tomography and transthoracic echocardiography revealed bilateral ground-glass opacities and consolidation, deep venous thrombosis, acute pulmonary artery embolism, and acute arterial embolism that appeared to originate from thrombus in the left ventricle. Combination of a neuraminidase inhibitor, antibiotics, an anticoagulant, and anti-platelet agent improved these complications; however, amputation of the patient's right foot was required. Because influenza can cause vascular events, physicians should pay attention to this complication in patients with influenza-associated pneumonia.

Keywords: Acute arterial embolism; Deep venous thrombosis; Gangrene; Influenza; Pneumonia.

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Figures

Fig. 1
Fig. 1
Appearance of the right foot. The patient's toes were pale on admission (a), and enhanced computed tomography showed contrast delay in the lower extremities (b). This condition progressed to gangrene by hospital day 18 (c).
Fig. 2
Fig. 2
Echocardiographic and chest and imaging on admission. Thrombus was detected in the left ventricle by transthoracic echocardiography (arrow) (a). Chest X-ray on admission showed bilateral consolidations and cardiomegaly (b). Chest computed tomography (CT) showed bilateral consolidations and ground-glass opacities (c). Enhanced CT showed filling defects in the pulmonary arteries (d).
See this image and copyright information in PMC

References

    1. Bunce P.E., High S.M., Nadjafi M., Stanley K., Liles W.C., Christian M.D. Pandemic H1N1 influenza infection and vascular thrombosis. Clin. Infect. Dis. 2011;52:e14–e17. - PubMed
    1. Hüzmeli C., Saglam M., Arıkan A., Doner B., Akıncı G., Candan F. Infrarenal aorta thrombosis associated with H1N1 influenza A virus infection. Case Rep. Infect. Dis. 2016;2016:9567495. - PMC - PubMed
    1. Louria D.B., Blumenfeld H.L., Ellis J.T., Kilbourne E.D., Rogers D.E. Studies on influenza in the pandemic of 1957-1958. II. Pulmonary complications of influenza. J. Clin. Investig. 1959;3:213–265. - PMC - PubMed
    1. Ishiguro T., Kagiyama N., Uozumi R., Odashima K., Takaku Y., Kurashima K., Morita S., Takayanagi N. Clinical characteristics of influenza-associated pneumonia of adults: clinical features and factors contributing to severity and mortality. Yale J. Biol. Med. 2017;90(2):165–181. - PMC - PubMed
    1. Kwong J.C., Schwartz K.L., Campitelli M.A., Chung H., Crowcroft N.S., Karnauchow T., Katz K., Ko D.T., McGeer A.J., McNally D., Richardson D.C., Rosella L.C., Simor A., Smieja M., Zahariadis G., Gubbay J.B. Acute myocardial infarction after laboratory-confirmed influenza infection. N. Engl. J. Med. 2018;378(4):345–353. - PubMed

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