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. 1987 Dec 1;248(2):483-7.
doi: 10.1042/bj2480483.

Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites

L F Morton  1 , C M Fitzsimmons, J Rauterberg, M J Barnes
Affiliations

Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites

L F Morton et al. Biochem J. .

Abstract

Collagen type III possesses a highly reactive platelet-aggregatory site at a locus which in type I is essentially inactive whilst the latter collagen possesses reactive sites absent in type III. It is proposed that platelet aggregation by collagen involves the sequence GK[or R]PG(EY)GPK[or R]G(EY) or, less favourably, GPK[or R]G(EY)G(XY)GK[or R]PG(EY), one basic residue acting in combination with the second in an adjacent alpha-chain.

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