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Case Reports
. 2019 Jun 27;19(1):156.
doi: 10.1186/s12872-019-1135-y.

Acute myocardial infarction and transient elevated anticardiolipin antibody in a young adult with possible familial hypercholesterolemia: a case report : Anticardiolipin antibody and myocardial infarction

Xin Su  1   2 , Aqian Wang  1   2 , Hai Zhu  1 , Hongling Su  1 , Yichao Duan  1   3 , Shanlian Wu  2 , Min Zhang  4 , Yan Huang  1 , Xing Zhou  5 , Yunshan Cao  6
Affiliations
Case Reports

Acute myocardial infarction and transient elevated anticardiolipin antibody in a young adult with possible familial hypercholesterolemia: a case report : Anticardiolipin antibody and myocardial infarction

Xin Su et al. BMC Cardiovasc Disord. .

Abstract

Background: Familial hypercholesterolemia (FH) can lead to premature coronary heart disease. Anticardiolipin antibody may be a contributor for thrombosis. Here, we report an adult with possible FH suffered from premature myocardial infarction that may be triggered by transient increased anticardiolipin antibody.

Case presentation: A 29-year-old male had presented with a history of 2-h chest pain and numbness of left upper arm before 5 days. The electrocardiogram (ECG) had demonstrated inferior wall myocardial infarction (MI). Five days later he was admitted to our hospital and diagnosed as acute MI and possible FH (premature coronary heart disease, low density lipoprotein cholesterol of 5.90 mmol/L) with increased anticardiolipin antibody (up to 120 RU/ml). Other auto-antibodies including β2-glicoprotein antibodies IgM, IgA, IgG, lupus anticoagulant (LA), antinuclear antibodies, anti-myocardial antibody were normal. Coronary artery angiography (CAG) showed right coronary artery was total occlusion from the middle segment. Then he underwent percutaneous coronary intervention with a stent. Four days later, he was discharged with complete recovery. CAG showed intra-stent restenosis and anticardiolipin antibody level was normal and the patient had no any symptoms at 6-month follow-up.

Conclusions: Transient elevated anticardiolipin antibody may be a trigger or biomarker of cardiac thrombotic events in younger atherosclerotic patients.

Keywords: Anticardiolipin antibody; Familial hypercholesterolemia; Myocardial infarction; Thrombosis.

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Conflict of interest statement

The authors have no any conflicts of interests to disclose.

Figures

Fig. 1
Fig. 1
Electrocardiogram at admission
Fig. 2
Fig. 2
Coronary artery angiography and percutaneous coronary intervention (PCI). a. Left anterior descending artery (LAD); b. Right coronary artery (RCA); c. Implantation of stent in the middle right coronary artery
Fig. 3
Fig. 3
Electrocardiogram at discharge
Fig. 4
Fig. 4
Electrocardiogram at 6-month follow-up
See this image and copyright information in PMC

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