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. 2020 Mar;105(3):e121-e123.
doi: 10.3324/haematol.2019.219725. Epub 2019 Jun 27.

Conditions associated with polyclonal hypergammaglobulinemia in the IgG4-related disease era: a retrospective study from a hematology tertiary care center

Eric J Zhao  1 , Mollie N Carruthers  2 , Charles H Li  1 , Andre Mattman  3 , Luke Y C Chen  4
Affiliations

Conditions associated with polyclonal hypergammaglobulinemia in the IgG4-related disease era: a retrospective study from a hematology tertiary care center

Eric J Zhao et al. Haematologica. 2020 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Serum IgG4 level according to diagnosis. IgG subclass information was available for 50 of the 66 patients. Each boxplot has a median line, with the hinges marking the 25th and 75th percentiles, and whiskers extending at most to values 1.5 times the interquartile range. Exact values are overlaid as dot plots. Blue dots represent values for patients with histologically confirmed IgG4-RD. Dashed line: 1.25 g/L, upper limit of normal serum IgG4 level in our laboratory.
Figure 2
Figure 2
Concentrations of immunoglobulin subclasses according to diagnosis. IgM, IgA, and IgG subclasses for each of the 50 patients with IgG subclass data, grouped by diagnosis. Two patients with autoimmune conditions did not have IgM or IgA results and are marked by *.
See this image and copyright information in PMC

References

    1. Massonnet B, Delwail A, Ayrault JM, Chagneau-Derrode C, Lecron JC, Silvain C. Increased immunoglobulin A in alcoholic liver cirrhosis: Exploring the response of B cells to Toll-like receptor 9 activation. Clin Exp Immunol. 2009; 158 (1):115–124. - PMC - PubMed
    1. Zemlin AE, Ipp H, Maleka S, Erasmus RT. Serum protein electrophoresis patterns in human immunodeficiency virus-infected individuals not on antiretroviral treatment. Ann Clin Biochem. 2015; 52 (Pt 3):346–351. - PubMed
    1. Watanabe N, Kobayashi M, Shigeta Y, Hara H. Chronic idiopathic neutropenia with hypergammaglobulinemia. Jpn J Med. 1987; 26 (1):65–68. - PubMed
    1. Nocturne G, Mariette X. B cells in the pathogenesis of primary Sjogren syndrome. Nat Rev Rheumatol. 2018; 14 (3):133–145. - PubMed
    1. Dispenzieri A, Gertz MA, Therneau TM, Kyle RA. Retrospective cohort study of 148 patients with polyclonal gammopathy. Mayo Clin Proc. 2001; 76 (5):476–487. - PubMed

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