Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2019 May 23:2019:9392780.
doi: 10.1155/2019/9392780. eCollection 2019.

Nonclosure of the Peritoneum during Appendectomy May Cause Less Postoperative Pain: A Randomized, Double-Blind Study

Huseyin Kazim Bektasoglu  1 , Mustafa Hasbahceci  2 , Samet Yigman  1 , Erkan Yardimci  1 , Enver Kunduz  1 , Fatma Umit Malya  1
Affiliations
Randomized Controlled Trial

Nonclosure of the Peritoneum during Appendectomy May Cause Less Postoperative Pain: A Randomized, Double-Blind Study

Huseyin Kazim Bektasoglu et al. Pain Res Manag. .

Abstract

Objective: We aim to evaluate the effect of peritoneal closure on postoperative pain and life quality associated with open appendectomy operations.

Methods: This is a single-center, prospective, randomized, and double-blinded study. Here, 18-65-year-old patients who underwent open appendectomy for acute appendicitis were included. Demographic data of the patients, operation time, length of hospital stay, pain scores using a 10 cm visual analogue scale (VAS) on the first postoperative day, quality of life assessment using the EuroQol-5D-5L questionnaire on postoperative 10th day, deep wound dehiscence, bowel obstruction, and mortality data were recorded.

Results: In total, 112 patients were included in the study. The demographic data showed no significant difference between the groups. The median VAS score was lower in the group with open peritoneum, but this difference was not statistically significant (3 vs. 4, p=0.134). The duration of surgery was significantly shorter in the peritoneal nonclosure group (31.0 ± 15.1 vs. 38.5 ± 17.5 minutes, p=0.016). Overall complication rates and life quality test (EuroQol-5D-5L) results were similar between groups.

Conclusion: Nonclosure of the peritoneum seems to shorten the duration of surgery without increasing complications during open appendectomy. Postoperative pain and life quality measures were not affected by nonclosure of the peritoneum. This trial is registered with NCT02803463.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram of patients enrolled in the study.
Figure 2
Figure 2
Postoperative VAS scores for pain. VAS scores for pain at postoperative day 1 are also shown. Each group includes 56 patients. Square plots show mean values (3.6 vs. 4.1) and horizontal lines show confidence intervals (3.16–4.04 vs. 3.6–4.6) at 95% level. p value calculated using a Mann–Whitney U test.
Figure 3
Figure 3
EuroQol-5D5L index scores for life quality assessment. EuroQol-5D-5L index scores for life quality assessment at postoperative day 10 are also shown. The greater value indicates better health status. Each group includes 56 patients. Square plots show mean values (0.87 vs. 0.89) and horizontal lines show confidence intervals (0.836–0.904 vs. 0.856–0.924) at 95% level. p value calculated using a Student's t-test.
Figure 4
Figure 4
EuroQol-5D-5L VAS scores for overall health status assessment. EuroQol-5D-5L VAS scores for overall health status assessment by the patient at postoperative day 10 are also shown. The greater value indicates better health status. Each group includes 56 patients. Square plots show mean values (83.84 vs. 84.2) and horizontal lines show confidence intervals (79.9–87.8 vs. 81–87.4) at 95% level. p value calculated using a Student's t-test.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Callahan M. J., Rodriguez D. P., Taylor G. A. CT of appendicitis in children. Radiology. 2002;224(2):325–332. doi: 10.1148/radiol.2242010998. - DOI - PubMed
    1. Ingraham A. M., Cohen M. E., Bilimoria K. Y., Pritts T. A., Ko C. Y., Esposito T. J. Comparison of outcomes after laparoscopic versus open appendectomy for acute appendicitis at 222 ACS NSQIP hospitals. Surgery. 2010;148(4):625–637. doi: 10.1016/j.surg.2010.07.025. - DOI - PubMed
    1. Cipe G., Idiz O., Hasbahceci M., et al. Laparoscopic versus open appendectomy: where are we now? Chirurgia (Bucur) 2014;109(4):518–522. - PubMed
    1. Warren R. Primary closure of peritoneum in acute appendicitis with perforation: report of twenty cases. Annals of Surgery. 1939;110(2):222–230. doi: 10.1097/00000658-193908000-00005. - DOI - PMC - PubMed
    1. Kurek Eken M., Örek E., Tarhan T., et al. Effects of closure versus non-closure of the visceral and parietal peritoneum at cesarean section: does it have any effect on postoperative vital signs? A prospective randomized study. Journal of Maternal-Fetal & Neonatal Medicine. 2017;30(8):922–926. doi: 10.1080/14767058.2016.1190826. - DOI - PubMed

Publication types

Associated data