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. 1979 Jan;22(1):91-104.

The role of central 5-hydroxytryptamine in acupuncture analgesia

C S Han, P H Chou, C C Lu, L H Lu, T H Yang, M F Jen
  • PMID: 312529

The role of central 5-hydroxytryptamine in acupuncture analgesia

C S Han et al. Sci Sin. 1979 Jan.

Abstract

The role played by central 5-hydroxytryptamine (5-HT) in acupuncture analgesia (AA) has been studied in rats with the tail-flick response as the antinociceptive test. The analgesic effect of acupuncture can be enhanced or lowered by the increment or the decrement of the 5-HT level in the CNS. Furthermore, the turnover rate of 5-HT in the CNS has been found to be greatly facilitated during the period of acupuncture. The results imply that 5-HT in the CNS may be one of the most important neurochemical agents mediating AA.

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