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. 2019 Dec;47(12):1513-1515.
doi: 10.1016/j.ajic.2019.05.001. Epub 2019 Jun 26.

Antimicrobial stewardship impact on Pseudomonas aeruginosa susceptibility to meropenem at a tertiary pediatric institution

Jeremy S Stultz  1 , Sandra R Arnold  2 , Chasity M Shelton  3 , Bindiya Bagga  2 , Kelley R Lee  3
Affiliations

Antimicrobial stewardship impact on Pseudomonas aeruginosa susceptibility to meropenem at a tertiary pediatric institution

Jeremy S Stultz et al. Am J Infect Control. 2019 Dec.

Abstract

An antimicrobial stewardship program was implemented throughout 2012 at a tertiary pediatric institution with guideline development preceding prospective audit and feedback starting in 2013. Meropenem use decreased over 62% during the next 5 years. Non-cystic fibrosis Pseudomonas aeruginosa isolate susceptibility to meropenem increased from 89% in 2011 to 98% in 2017 (P < .001) and correlated with meropenem use the preceding year (Rs: -0.78, P = .008).

Keywords: Antimicrobial stewardship guidelines; Gram negative resistance; Guideline adherence; Microbial drug resistance; Prospective audit and feedback.

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