Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Sep 15:334:576997.
doi: 10.1016/j.jneuroim.2019.576997. Epub 2019 Jun 19.

Intrathecal rituximab in immunoglobulin G4-hypertrophic pachymeningitis

Carolina Soares  1 , Diana F Martins  2 , Roberto Pestana-Silva  2 , Mrinalini Honavar  3 , Olinda Faria  4 , Pedro Abreu  5 , Andreia Costa  5
Affiliations
Case Reports

Intrathecal rituximab in immunoglobulin G4-hypertrophic pachymeningitis

Carolina Soares et al. J Neuroimmunol. .

Abstract

We describe the case of a 69-year-old man who presented with symptoms of headache and severe vision loss due to G4 immunoglobulin (IgG4) hypertrophic pachymeningitis (HP). The patient was initially responsive to corticotherapy, but vision loss progressed when steroid therapy was first tapered. No improvement was noticed with intravenous rituximab. The patient showed clinical and radiological improvement after intrathecal rituximab, which can be an efficacious alternative treatment option.

Keywords: Hypertrophic pachymeningitis; IgG4 disease; Intrathecal rituximab.

PubMed Disclaimer

Publication types